Those of us who treat heart disease deal with controversies on a daily basis; but I am not sure that any topic provokes more passion and controversy than a discussion about the use of supplements for the treatment and prevention of cardiovascular (and other) disease. As medical doctors, we are trained to promote therapies grounded in ‘evidence” – that is, clinical trials and investigation. Unfortunately, most supplements and minerals have never been studied as thoroughly as drugs, so the “evidence” either for or against their use is lacking. Confusing this picture is that the proponents of supplement use may have an economic bias for their use, or their preference is based on their personal experience with a limited number of patients.